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Drugsoft drug data and web services
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Comparative Analysis of Drug Interaction Sources
Our drug interaction system is made of rules described in 5 major sources and applied to pharmacological classes which
extend the ATC classification. Our ATCx
classification is ATC compatible but is 2 levels deeper for specific products.
This part is a dynamic comparative analysis (based on current data) to compare the different sources used in
drug interaction detection.
These sources are checked for every rule present in our system. Our system states that a rule for a drug interaction
exists if this rule is either in SPC, Thesaurus ANSM, Hansten, Stockley or Tatro sources. Furthermore, the current set
of ATCx drug interaction rules, is based most often on the highest levels (1 or 2) of drug interactions as described
in each system.
We calculate here the percentage of rules not present at any level (not reported at all) in a given source.
As you can see the percentage of forgotten rules is pretty high. The reason can be linked to drugs
that are not or no more marketed in a given country, to the fact that the rule is not considered important or that
the rule is simply unknown by the source.
As we have very high scores of forgotten contraindications, and as many drugs are marketed worldwide, we cannot rule out
that these omissions may be the result of a lack of drug interaction compilation. We try to cover 100% of ANSM rules
but many rules described in Hansten, Stockley or Tatro (usually not major drug interactions) are not in our sytem.
We conclude that no source alone (even our system) can be used to properly detect drug interactions, so please check
at least the Summary of Product Characteristics of the drugs you combine. Our work try to
contribute to the improvement of drug interaction detection.
| Comparative Analysis of Drug Interaction Source Accuracy |
| ATCx based Drug Interaction Rules (19 Jun 2013) |
% of Rule omission in a given source (not reported at all) |
| Total |
Level |
SPC |
ANSM |
Hansten |
Stockley |
Tatro |
| 1251 rules |
C |
48 (3%) |
617 (49%) |
749 (59%) |
292 (23%) |
605 (48%) |
| 2239 rules |
D |
298 (13%) |
1282 (57%) |
1422 (63%) |
589 (26%) |
1282 (57%) |
| 4744 rules |
P |
989 (20%) |
2964 (62%) |
2944 (62%) |
1043 (21%) |
2478 (52%) |
| 8234 rules |
All |
1335 (16%) |
4863 (59%) |
5115 (62%) |
1924 (23%) |
4365 (53%) |
Level C stands for Contraindicated, D (Discouraged or Déconseillé) for not recommended and P for Precaution or caution
SPC stands for Summary of Product Characteristics (interactions described in)
ANSM (Agence Nationale de Sécurité du Médicament) stands for Thesaurus des Interactions médicamenteuses, ANSM, mises à jour de décembre 2010, septembre 2011, mars 2012, décembre 2012
Hansten stands for Hansten PD et al. Drug Interaction Analysis and Management, Wolters Kluwer Health. 2009, 2010, 2011, 2012
Stockley stands for Stockley's Drug Interactions, Karen Baxter. Pocket Companion, 2009, 2010, 2011, 2012 and the last full version, the ninth edition 2010
Tatro stands for Tatro DS et al. Drug Interaction Facts, Wolters Kluwer Health. 2009, 2010, 2011, 2012
